Cumulative Exposure and Health Risk Assessment of PFAS in Animal-Derived Foods Using the Relative Potency Factor Approach.

ABSTRACT: Per- and polyfluoroalkyl substances (PFASs) are persistent and bioaccumulative contaminants frequently detected in animal-derived foods, raising concerns for consumer health. In 2020, the European Food Safety Authority (EFSA) established a group tolerable weekly intake (TWI) of 4.4 ng/kg bw per week for four PFAS (PFOA, PFNA, PFOS, PFHxS) based on immunotoxicity, prompting the European Commission to set maximum levels in food. However, many other PFAS are present in the diet, and their cumulative risk is poorly characterized. This study applied the Relative Potency Factor (RPF) approach, using hepatic toxicity as the reference endpoint. The RPF approach addresses a key challenge in assessing human dietary exposure to PFAS by enabling cumulative risk assessment for complex mixtures found in

SUBMITTER: Rampazzo G 

PROVIDER: S-EPMC12656023 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature