Transcriptomics-Based Toxicological Study of Nickel on <i>Caenorhabditis elegans</i>.

ABSTRACT: Nickel (Ni), a heavy metal with extensive industrial applications, poses significant ecological impacts and health risks due to its persistence and bioaccumulation. Although toxicological data in mammals and plants are well established, its effects on invertebrate models remain insufficiently explored, especially at environmentally relevant concentrations. This study systematically evaluated the toxicity of Ni²⁺ on Caenorhabditis elegans, integrating phenotypic assays with transcriptomic profiling to assess impacts on growth, reproduction, neuromuscular function, lifespan, and aging. Ni exposure induced dose-dependent developmental delays. After exposure to 80 μg/L Ni²⁺ for 72 h, the proportion of L1-stage nematodes increased 3.8-fold compared to the control gr

SUBMITTER: He Y 

PROVIDER: S-EPMC12656052 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature