Associations between medication use and multiple domains of cognitive function in people with multiple Sclerosis.

ABSTRACT:

Background

People with multiple sclerosis (MS) often use multiple medications concurrently to manage a wide range of symptoms. Although polypharmacy is associated with cognitive impairment, the effects of specific medication classes on cognitive outcomes in MS remain poorly understood. This study examined associations between commonly used medications and both objective and subjective measures of cognitive function in people with MS.

Method

A secondary analysis of baseline data from a longitudinal study in 260 individuals with MS was conducted. Current medication use was self-reported. Objective cognitive function was assessed across multiple domains using the NIH Toolbox Cognitive Battery and the Symbol Digit Modalities Test, Paced Auditory Serial Addition Test, and Rey Aud

SUBMITTER: Kim J 

PROVIDER: S-EPMC12656195 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature