Biocompatibility and Safety of 3D Printing Resins for Orthodontic Aligners: A Critical Review of Current Evidence.

ABSTRACT: Orthodontic aligners 3D-printed in resin currently provide a viable alternative to thermoformed ones. However, concerns have been raised regarding their biocompatibility. This review addressed the available scientific evidence on the biological properties of marketed resins for 3D printing of orthodontic aligners, encompassing cytotoxicity, estrogenicity, biofilm formation, and oral soft tissues reactions. A comprehensive literature search of several databases was conducted and PRISMA guidelines were followed to summarize the retrieval. Eleven studies were included in the review. They provided information on only three marketed resins: Tera Harz TC-85 DAC and Tera Harz TA-28 (Graphy) and Clear-A (Senertek). For the last two materials, only one investigation has been performed. Despite the

SUBMITTER: Goracci C 

PROVIDER: S-EPMC12656306 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature