The EIF2α-PERK Signaling Pathway Mediates Manganese Exposure-Induced A1-Type Astrocytes Activation via Endoplasmic Reticulum Stress.

ABSTRACT: Elevated exposure to manganese (Mn) has been linked to a broad spectrum of neurological disorders, including motor dysfunction. Neuroinflammation with excessively activated astrocytes plays a critical role in the pathogenesis and progression of neurodegenerative diseases. Astrocyte-mediated neuroinflammation plays a dual role due to distinct astrocyte phenotypes, including deleterious A1 and neuroprotective A2. Our previous studies have confirmed that Mn induces activation of astrocytes in the central nervous system, and endoplasmic reticulum (ER) stress has been verified to regulate A1 activation; however, the molecular mechanisms underlying Mn-induced neurotoxicity remain incompletely understood. We establish in vivo and in vitro Mn exposure models and observed that Mn induced A1 activat

SUBMITTER: Wang J 

PROVIDER: S-EPMC12656517 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature