Isolation and Characterization of a Novel Thermostable Bacteriophage Targeting Multi-Drug-Resistant <i>Salmonella</i> Enteritidis.

ABSTRACT: (1) Background: The emergence of multidrug-resistant (MDR) Salmonella enterica poses a major threat to global public health, underscoring the urgent need for alternative therapeutic strategies. Bacteriophages represent a promising alternative due to their high specificity and potent ability to lyse MDR strains. (2) Methods: In this study, we isolated a novel MDR Salmonella Enteritidis-targeting bacteriophage from Lebanese sewage and characterized its host range, thermal and pH stability, and infection dynamics. Whole-genome sequencing was performed using Illumina technology to determine its genetic features and taxonomic classification. (3) Results: the bacteriophage was classified within the genus Jerseyvirus and the class Caudoviricetes with a 43 kb dsDNA geno

SUBMITTER: Almashtoub SA 

PROVIDER: S-EPMC12656726 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature