Recombinant Extracellular Factor Protein of <i>Streptococcus suis</i> as Potential Candidate Protein for Antibodies Against <i>S. suis</i> Detection and Subunit Vaccine Development: <i>In Silico</i> and <i>In Vitro</i> Approaches.

ABSTRACT: Background/Objectives: Streptococcus suis is a zoonotic pathogen that causes infections in pigs and humans, leading to significant economic losses. S. suis can evade the immune system of hosts and induce persistent infections. Early detection and vaccination are crucial for controlling the disease in swine industries. This study aimed to investigate candidate recombinant protein for antibodies against S. suis detection and subunit vaccine development. Methods: The whole genome of S. suis BM407 was analyzed using bioinformatic tools to predict suitable proteins and genes for recombinant protein expression. Partial extracellular factor protein (epf) genes of S. suis serotype 2 DMST18783 were amplified. A 3301 bp amplicon was digested, a

SUBMITTER: Mitsuwan W 

PROVIDER: S-EPMC12656778 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature