Cytokine and Antibody Isotype Responses in Vaccinated Healthcare Workers with SARS-CoV-2 Breakthrough Infections.

ABSTRACT:

Background

Healthcare workers (HCWs) are at high risk of breakthrough SARS-CoV-2 infections despite complete vaccination schedules. There are gaps in our understanding of the specific antibody isotypes and cytokine profiles produced during an infection following vaccination. In this study, we evaluated SARS-CoV-2^-specific antibody isotypes and their association with cytokine production in HCWs with breakthrough infections.

Methods

Serum samples from 114 HCWs were analyzed for antibody isotypes against the nucleoprotein (NCP) and the receptor binding domain (RBD) of the spike protein, as well as for a panel of 13 cytokines.

Results

Vaccinated SARS-CoV-2⁺ HCWs showed a higher prevalence of anti-SARS-CoV-2 antibodies against NCP (IgM = 93.8%, IgG =

SUBMITTER: Fernandez-Rojas MA 

PROVIDER: S-EPMC12656851 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature