Molecular Responses to Avian Reovirus Inoculation In Vitro.

ABSTRACT: Avian reovirus (ARV) is an important pathogen of poultry, yet the molecular responses to ARV across cell types remain unknown. The present study explores the differential transcriptomic responses to ARV S1133 infection in three cell types, i.e., chicken embryo kidney (CEK), chicken embryo liver (CELi), and macrophage-derived cells (HD11) at 6, 12, and 24 h post-inoculation (hpi). CELi cells exhibited the highest viral replication rates at all timepoints, with maximal titer observed at 24 hpi, whereas HD11 cells showed limited viral replication but extensive host transcriptional activity. Differential gene expression analysis revealed that macrophage-derived (HD11) cells, despite the lower viral load, presented the most pronounced transcriptional changes. CEK cells demonstrated a unique act

SUBMITTER: Khalid Z 

PROVIDER: S-EPMC12656875 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature