Multidrug-Resistant <i>Enterococcus faecalis</i> from Yak Feces: Isolation, Genomic Characterization and Functional Insights.

ABSTRACT: Enterococcus faecalis (E. faecalis) is a significant zoonotic pathogen, primarily causing opportunistic infections in humans while often existing as a commensal in animal reservoirs, facilitating its dissemination. Current understanding of the resistance profiles, virulence mechanisms, and host-pathogen interactions of E. faecalis from ruminants, particularly unique species such as the plateau yak, remains limited. This knowledge gap hinders the accurate assessment of their transmission risk and the development of effective control strategies. This study presents a comprehensive analysis of a multidrug-resistant E. faecalis isolate from yak feces, integrating whole-genome sequencing (WGS), an animal challenge model, and transcriptomic profiling. Antimicrobial su

SUBMITTER: Huang J 

PROVIDER: S-EPMC12656877 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature