MicroRNA Expression Profiling in Canine Myxomatous Mitral Valve Disease Highlights Potential Diagnostic Tool and Molecular Pathways.

ABSTRACT: Myxomatous mitral valve disease (MMVD) is the most common acquired cardiac disoder in dogs and a relevant model for human mitral valve disease. However, the molecular drivers of disease progression remain unclear, and reliable biomarkers for early diagnosis still hamper clinical management. This study investigated microRNA (miRNA) expression directly in histologically characterized mitral valve tissues. Formalin-fixed paraffin-embedded samples were obtained from control dogs (n = 7), low-grade MMVD (n = 8), and high-grade MMVD (n = 5). A bioinformatics workflow identified candidate miRNAs converging on extracellular matrix remodeling and canonical signaling pathways, including TGF-β, PI3K-Akt, and MAPK. Selected candidates, let-7 family, miR-98, miR-21, miR-30b, miR-13

SUBMITTER: Guelfi G 

PROVIDER: S-EPMC12656886 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature