Vaccine-Associated Autoimmunity: From Clinical Signals to Immune Pathways.

ABSTRACT: COVID-19 vaccination has played a pivotal role in mitigating the global health crisis and reducing morbidity and mortality associated with SARS-CoV-2 infection. While its public health benefits are unequivocal, the unprecedented scale of vaccination-reaching billions worldwide-has also enabled the detection of rare autoimmune events, including systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, and Guillain-Barré syndrome. Although such events occur in only a small subset of individuals, often influenced by genetic, environmental, or dosage-related factors, they underscore the importance of understanding immune tolerance mechanisms in vaccination. This review synthesizes clinical observations and immunological findings from the COVID-19 vaccination era, highlighting key me

SUBMITTER: Peng M 

PROVIDER: S-EPMC12656999 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature