<i>Lactobacillus reuteri</i>-derived HDCA suppresses PEDV replication while alleviating virus-triggered inflammation in piglets.

ABSTRACT:

Background

Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea, vomiting, and high mortality in neonatal piglets, but no fully effective treatments or vaccines are currently available. Although gut microbiota transplantation can alleviate post infection symptoms, the specific protective bacterial strains or metabolites involved, along with their underlying mechanisms of action against PEDV, remain unclear.

Results

Oral administration of L. reuteri GZ-1 or its metabolite hyodeoxycholic acid (HDCA) to three-day-old piglets significantly mitigated clinical symptoms and improved survival outcomes following PEDV challenge. This protection was achieved through five-day pretreatment preceding viral exposure. Both interventions substantially preserved the intestinal

SUBMITTER: Bian Z 

PROVIDER: S-EPMC12657016 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature