Is the vaccination-induced B cell receptor repertoire predictable?

ABSTRACT: Vaccines trigger an immune response that results in a population of memory cells that can quickly respond to subsequent antigen re-encounters. Most vaccines are designed to induce memory B cells with vaccine-specific B cell receptors (BCRs). Post-vaccination, clonal expansion of B cells results in measurably expanded vaccine-specific BCR clonotypes. We set out to determine to what extent it is predictable which specific BCR clonotypes are vaccine-induced in an individual. We sequenced the BCR heavy chain repertoire in a cohort of 19 individuals prior- and 7 days post Tdap booster vaccination. We tested two modalities to predict which clonotypes were expanded post-vaccination: first, we utilized a small database of monoclonal antibodies with known specificity to Tdap vaccine antigens and te

SUBMITTER: Richardson E 

PROVIDER: S-EPMC12657037 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature