Genomic Epidemiology of Clonal Complex 1 <i>Staphylococcus aureu</i>s in Remote Western Australian Communities.

ABSTRACT: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) was first reported in Western Australia (WA) in the 1990s. Although ST8-IVa [2B] (WA-5) was the first identified CA-MRSA in WA, ST1-IVa [2B] (WA-1) soon emerged as the dominant clone. To investigate the genomic epidemiology of clonal complex (CC) CC1 S. aureus in WA Aboriginal communities from 1995 to 2003 and assess the acquisition and diversity of the SCCmec element, whole genome sequencing was performed. Three sequence types (STs) were identified: ST1 (81.4%), ST761 (0.9%) and ST762 (17.8%). MRSA constituted 78% (n = 92) of the collection and all harboured SCCmec Type IVa [2B]. Panton-Valentine leukocidin (PVL)-encoding genes were identified in seven closely related isolates. Th

SUBMITTER: Yee NWT 

PROVIDER: S-EPMC12657077 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature