Thoracic vertebral bone mineral density measured by quantitative computed tomography is associated with fracture risk in lung cancer screening populations: a prospective cohort study.

ABSTRACT:

Background

Chest low-dose computed tomography (LDCT) is extensively utilized for lung cancer screening, offering a concurrent opportunity to assess thoracic vertebral bone mineral density (BMD) using quantitative computed tomography (QCT). Nonetheless, the value of thoracic BMD (TBMD) in estimating the risk of fractures within this population remains underexplored.

Purpose

We sought to assess the association between fractures and QCT-based TBMD derived from chest LDCT in a lung cancer screening population.

Materials and methods

A prospective study was conducted involving 546 adults aged 40 to 74 years who were enrolled in a lung cancer screening program between 2017 and 2021. TBMD and lumbar BMD (LBMD) were assessed from chest LDCT scans using QCT. Self-reported incid

SUBMITTER: Jiang W 

PROVIDER: S-EPMC12657172 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature