Robust noninvasive detection of hyperglycemia in mouse models of metabolic dysregulation using the novel Urination Index biomarker.

ABSTRACT: Blood glucose is one of the most essential parameters in metabolic research. Yet, accurate blood glucose monitoring in mouse models of diabetes is challenging owing to the substantial stress associated with the measurements and the variability in diabetes development among experimental mouse models. This variability requires frequent blood glucose measurements, which provide only intermittent data and may not accurately reflect continuous metabolic changes. Here, to address these issues, we have utilized the Tecniplast DVC system to monitor bedding moisture, enabling the detection of increased urination (polyuria) in mice, a primary symptom of diabetes. Polyuria is a hallmark of (undiagnosed/untreated) diabetes, and we revealed high correlations between bedding moisture and blood glucose d

SUBMITTER: Brachs S 

PROVIDER: S-EPMC12657215 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature