Combined Influence of Depressive Symptoms and Estimated Glomerular Filtration Rate on Cognition Decline in US Adults.

ABSTRACT:

Background

Cognitive decline is common in older adults and may be influenced by both depressive symptoms and kidney function.

Methods

We analyzed 2650 participants aged ≥ 60 years from NHANES 2011-2014. Depressive symptoms were defined as PHQ-9 ≥ 10, and eGFR was calculated using the CKD-EPI equation. Cognitive decline was defined as the lowest quartile of a composite score from CERAD, AFT, and DSST tests. Weighted logistic regression, restricted cubic spline, and mediation analyses were applied.

Results

Depressive symptoms (OR = 3.14, 95% CI: 1.91-5.19) and reduced eGFR < 60 mL/min/1.73 m² (OR = 2.13, 95% CI: 1.25-3.61) were independently associated with a higher risk of cognitive decline. Participants with both depressive symptoms and low eGFR had the gre

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12657257 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature