Characteristics and outcomes of Kaposi sarcoma herpesvirus-associated inflammatory cytokine syndrome.

ABSTRACT:

Abstract

Kaposi sarcoma-associated herpesvirus (KSHV) inflammatory cytokine syndrome (KICS) is characterized by KSHV infection and severe inflammatory symptoms and signs (elevated cytokines, C-reactive protein, and KSHV viremia), without evidence of other causes. The primary objective of this study was to evaluate KICS natural history after exclusion of other inflammatory disorders, including multicentric Castleman disease (MCD) and, per a revised working definition, primary effusion lymphoma (PEL). Participants with KICS were treated for concurrent Kaposi sarcoma (KS) and/or received KICS-directed treatment with targeted therapies used in other KSHV-associated disorders (KAD), such as rituximab, tocilizumab, or high-dose valganciclovir/azidothymidine. KICS response was evaluated u

SUBMITTER: Ramaswami R 

PROVIDER: S-EPMC12657280 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature