Power Spectral Slope as a Novel Brain Functional Marker for Major Depressive Disorder.

ABSTRACT:

Background

Resting-state functional magnetic resonance imaging (rs-fMRI) is a powerful tool to reveal disrupted brain activity in major depressive disorder (MDD), but most studies have focused solely on low-frequency functional fluctuations, ignoring the fact that brain activity is composed of both low-frequency and high-frequency fluctuations. Therefore, we applied a novel approach, namely the power spectral slope (PSS), which captures the characteristics of both low- and high-frequency fluctuations to evaluate brain activity in MDD.

Methods

rs-fMRI data were collected from 109 patients with MDD (27.29 ± 7.11 years, 75 women) and 78 normal control participants (26.47 ± 6.19 years, 51 women). A subset of 52 patients with MDD also underwent rs-fMRI scanning after a 12-week an

SUBMITTER: Zhou H 

PROVIDER: S-EPMC12657283 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature