Association Between Maternal Genome-Wide Polygenic Scores for Psychiatric and Neurodevelopmental Disorders and Adverse Perinatal Events: A Danish Population-Based Study.

ABSTRACT:

Background

Phenotypic links between psychiatric disorders and adverse perinatal events are increasingly being reported, but the mechanisms remain unclear. In this study, we aimed to assess how polygenic scores (PGSs) for 8 psychiatric conditions influence perinatal risk.

Methods

The main analysis included 13,085 mothers and their corresponding birth information. PGSs for psychiatric conditions were estimated using genome-wide association study data (excluding the iPSYCH cohort) via LDpred2 and used as exposures. Ten adverse perinatal events from Danish national registers served as outcomes. Associations were analyzed using logistic or multinomial regression, with false discovery rate correction applied.

Results

We found that PGSs for psychiatric conditions were associ

SUBMITTER: Ge F 

PROVIDER: S-EPMC12657294 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature