A comparison of theacrine and methylliberine with caffeine as salivary markers for determining gastric emptying.

ABSTRACT: Gastric emptying is a critical determinant of the pharmacokinetics of orally administered drugs. A key limitation in studies using caffeine as a marker for gastric emptying is the requirement for prior caffeine abstinence, which can complicate study design and participant recruitment. The present study was conducted with the objective of evaluating the potential use of the methylurates methylliberine and theacrine as novel salivary markers for the assessment of gastric emptying of non-caloric liquids, in comparison to the established marker caffeine. A Salivary Tracer Technique (STT) was employed in a crossover study that involved twelve healthy volunteers. The subjects participating in the study were under fasted state conditions according to the guidelines of the Food and Drug Administra

SUBMITTER: Wildgrube T 

PROVIDER: S-EPMC12657313 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature