Immune cell profiling of peripheral blood in long-term testicular germ cell tumor survivors.

ABSTRACT:

Introduction

This study addresses changes in peripheral blood immune cell composition and possible late effects of curative treatment in testicular germ cell tumors (GCT) survivors.

Methods

We analyzed the immunophenotype in peripheral blood obtained from 202 survivors treated at the National Cancer Institute in Bratislava by flow cytometry. The median long-term follow-up was 13 years (1-35). We divided the survivors into groups as follows: CT-chemotherapy (N = 141), RT-radiotherapy (N = 16), CTRT - chemotherapy + radiotherapy (N = 13), and the control group of patients under active surveillance - AS (N = 32).

Results

Survivors treated with AS had a lower number of B-cells (mean ± standard deviation (SD) = 10.3 ± 3.5 vs 11.9 ± 4.2, p=0.04) compared to the CT group. Su

SUBMITTER: Kilikova K 

PROVIDER: S-EPMC12657365 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature