Mid- and late-life cardiovascular health indicators and changes in biological ageing Markers; A multi-cohort study.

ABSTRACT:

Background

Cardiovascular (CV) health-related risk factors may influence the epigenetic-based pace of biological ageing (BA). However, given that early-life lifestyle factors can have lasting effects on DNA methylation (DNAm), observed associations may reflect cumulative exposures rather than short-term changes in older adults. We investigated whether CV risk factors are associated with changes in the pace of ageing in midlife and older adults.

Methods

We analysed baseline DNA methylation data from 4848 participants across three cohorts, AGES-RS (n = 2602), CARDIA (n = 1568), and InCHIANTI (n = 678), using Illumina arrays, with two to four time points per cohort. Pace of ageing was measured using DunedinPACE (DDPACE). Cardiovascular risk factors included smoking status, DNAm

SUBMITTER: Asefa NG 

PROVIDER: S-EPMC12657379 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature