Integrated analysis of N-glycosylation and Alzheimer's disease: identifying key biomarkers and mechanisms.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most prevalent cause of dementia in the elderly, imposing a significant societal burden. Current therapeutic approaches primarily address symptoms, underscoring the critical need to elucidate its pathogenesis and identify robust early biomarkers. N-glycosylation, a critical post-translational modification, is dysregulated in neurodegenerative disorders, yet its role in AD and diagnostic potential remain underexplored.

Objective

This investigation aimed to characterize the interplay between N-glycosylation and AD through multi-dimensional bioinformatics analysis, identify core differentially expressed genes (DEGs) associated with this crosstalk, and evaluate their diagnostic efficacy in early AD detection.

Methods

A bibliometr

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12657396 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature