A repository of the salivary metabolome and its key drivers in 1436 European children.

ABSTRACT:

Background

Saliva is an emerging but understudied biofluid in metabolomics, offering a similar window into biological information as blood, while enabling repetitive and non-invasive sampling.

Methods

In this observational study, we comprehensively analysed the salivary metabolome of 965 children and adolescents (7-17y) from two exploratory cohorts in Europe, using ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry. Preprocessed data were assessed via (partial) Spearman correlation, Mummichog-based pathway enrichment, and univariate (Welsh t-test, one-way ANOVA, Wilcoxon or Kruskal-Wallis rank-sum test) analyses. All p-values were corrected using the Benjamini-Hochberg procedure. Associations with age, anthropometrics, mental wellbeing,

SUBMITTER: De Paepe E 

PROVIDER: S-EPMC12657424 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature