Spatiotemporal dynamics of HIV-1 transmission networks in a major migration hub: integrated phylogenetic and molecular evidence.

ABSTRACT:

Objective

Human Immunodeficiency Virus type 1 (HIV-1) cross-regional transmission poses a critical challenge in China, particularly in high-mobility metropolitan centers. This study aimed to characterize the transmission dynamics between Hangzhou-a megacity with 11.9 million residents (42% migrants)-and other Chinese regions using molecular epidemiology.

Methods

We analyzed 4,249 Hangzhou-derived and 50,898 non-Hangzhou HIV-1 pol sequences. Molecular transmission network analysis was used to identify transmission clusters, and phylogenetic and Bayesian analyses were conducted to explore lineage characteristics, origins, and expansion of major clusters.

Results

Molecular transmission network analysis identified 3,317 clusters, incorporating 43.5% (1,848/4,249) of Hangz

SUBMITTER: Zhu M 

PROVIDER: S-EPMC12657489 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature