Dissociating the Role of Dorsolateral Prefrontal Cortex and Ventrolateral Prefrontal Cortex in Cognitive Control in Depression: A Combined HD-tDCS and fNIRS Study.

ABSTRACT: Major depressive disorder (MDD) is marked by cognitive and affective dysfunctions associated with altered prefrontal cortical activity. While high-definition transcranial direct current stimulation (HD-tDCS) shows promise in modulating these deficits, little is known about the differential effects of targeting specific prefrontal subregions. This study investigated whether HD-tDCS over the dorsolateral (DLPFC) or ventrolateral (VLPFC) prefrontal cortex produces distinct behavioural and neurophysiological effects in patients with MDD, focusing on cognitive control, mood, and functional brain connectivity. Twenty-six patients with MDD received ten sessions of HD-tDCS over the left DLPFC, left VLPFC, or sham stimulation. Assessments were performed pre-intervention, post-intervention, and at o

SUBMITTER: Hernandez-Sauret A 

PROVIDER: S-EPMC12657566 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature