Mogroside V Ameliorates Spinal Cord Injury by Inhibiting M1 Microglia Polarization.

ABSTRACT: Spinal cord injury (SCI) constitutes a severe disorder of the central nervous system that is usually caused by external traumatic forces that damage the spinal cord's structure and disrupt its normal functions. SCI is characterized by a high disability rate and limited treatment options. The current treatments include surgery, medication, and rehabilitation. Additionally, some traditional Chinese medicines and their ingredients have shown potential effects in the treatment of SCI. Mogroside-V (Mog-V), derived from Siraitia grosvenorii, displays a range of biological functions, such as anti-inflammatory effects, antitumor actions, and antioxidant potential. However, the effect and fundamental mechanism of Mog-V on SCI remain unclear. In this study, we established a spinal cord contusion mod

SUBMITTER: Xie X 

PROVIDER: S-EPMC12657585 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature