Joint Association of Depression and Sleep Duration With All-Cause and Cardiovascular Mortality: A Cross-Sectional Study With Inflammation Mediation Analysis.

ABSTRACT:

Background and aims

The relationship between depression, sleep duration, and mortality outcomes remains incompletely elucidated. This study aimed to investigate the combined effects of depression and sleep duration on mortality risk, while also examining the potential mediating role of inflammatory markers in these associations.

Methods

The analysis included 41,346 adult participants from the US National Health and Nutrition Examination Survey (NHANES). Mortality outcomes were determined through linkage with the National Death Index (NDI) records up to December 31, 2019. Multivariate Cox proportional hazards regression models were employed to assess the associations between depression, sleep duration, and both all-cause and cardiovascular mortality. Additionally, the mediati

SUBMITTER: Li Y 

PROVIDER: S-EPMC12657627 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature