Admixture-mapping analysis reveals genetic determinants of the human plasma proteome.

ABSTRACT: Protein profiling and genetic findings can be integrated to define the genetic architecture of the circulating proteome in chronic diseases. Most self-identified African American (AA) individuals have both African and European genetic ancestry. Admixture mapping can detect genomic association regions in which causal variants exist with substantial differences in allele frequency or effect sizes between genetic ancestries. We performed admixture mapping of the circulating proteome in 1,989 participants from the Jackson Heart Study (JHS), investigating the relation of local African ancestry within genomic regions with levels of circulating proteins. We conditioned protein-local ancestry association models on variants previously found to be associated with those proteins in genome-wide associ

SUBMITTER: Cruz DE 

PROVIDER: S-EPMC12657719 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature