A retrospective evaluation of preemptive liver transplantation for bile duct dysplasia in primary sclerosing cholangitis: Balancing risks and benefits.

ABSTRACT:

Background & aims

Liver transplantation (LT) to prevent cholangiocarcinoma (CCA) in individuals with primary sclerosing cholangitis (PSC) and bile duct dysplasia was introduced in Norway and Sweden in the early 2000s. We aimed to evaluate this practice to potentially improve future selection of candidates for LT.

Methods

We conducted a retrospective study of 512 adults with PSC who underwent first-time LT between 2000-2021 at Oslo and Karolinska University Hospitals. Pre-LT findings in bile duct brush cytology and/or biopsy of low-grade dysplasia (LGD) and high-grade dysplasia (HGD) were compared with histological findings in the explanted livers and survival rates were assessed.

Results

Bile duct dysplasia, low-grade (LGD) or high-grade (HGD), was the primary LT indi

SUBMITTER: Breder S 

PROVIDER: S-EPMC12657721 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature