Cortical connectivity is associated with cognition across time in Parkinson's disease.

ABSTRACT: Cognitive symptoms are common in Parkinson's disease (PD) and have debilitating effects on quality of life and disease trajectory; however, the underlying brain mechanisms remain poorly understood. To address this gap, we investigated the relationship between functional connectivity and cognition at multiple time points using longitudinal functional MRI (fMRI) and cognitive assessments from the Parkinson's Progression Marker Initiative (PPMI). We calculated resting-state functional connectivity across three distinct time points. We analyzed functional connectivity within and between three key cortical brain networks that have been linked with higher-order cognitive function in PD: the frontoparietal network (FPN); the salience network (SAL); and the default mode network (DMN). Global cogni

SUBMITTER: Twedt HP 

PROVIDER: S-EPMC12657728 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature