Adipose microsomal triglyceride transfer protein deficiency protects against hepatic steatosis by upregulating PPARα activity.

ABSTRACT:

Background & aim

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing health issue. Identifying factors that prevent hepatic lipid accumulation could inform new MASLD prevention or treatment strategies. We previously demonstrated that adipocyte microsomal triglyceride transfer protein (MTP) regulates intracellular lipolysis by inhibiting adipose triglyceride lipase activity. The aim of this study was to investigate the impact of adipose MTP deficiency on MASLD.

Methods

We used previously described adipose-specific MTP knockout (A-Mttp ^-/- ) mice. Fat mobilization from adipose to liver was assessed using: (1) lipidomic profiling of plasma, epididymal fat, and liver, and (2) treatment of wild-type hepatocytes with conditioned m

SUBMITTER: Rajan S 

PROVIDER: S-EPMC12657731 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature