Increasing carbohydrates or nitrogenous compounds by cecal infusion leads to an opposite influence on colonic microbiota and host metabolism in a pig model.

ABSTRACT: Gut microbes, particularly those in the hindgut, play an important role in fermenting undigested nutrients (carbohydrates and proteins) and in regulating host metabolism via the gut-liver metabolic axis. However, the effects of variations in the ratio of carbohydrates to proteins on host metabolism remain largely unknown. In this study, we investigated the response of large intestinal microbiota and host metabolism to changes in nutrient substrate availability by infusing corn starch or casein hydrolysate via cecal cannulas. Twenty-four growing pigs with cecal cannulas were randomly divided into three groups (n = 8): a control group infused with saline; a starch group infused with corn starch; and a casein group infused with casein hydrolysate (50 g/d) dissolved in saline. The infus

SUBMITTER: Pi Y 

PROVIDER: S-EPMC12657759 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature