Understanding the Global Dynamics of Pyrethroid Resistance-related <i>kdr</i> mutations in <i>Aedes</i> (<i>Stegomyia</i>) <i>aegypti</i> (Linnaeus, 1762) (Diptera: Culicidae).

ABSTRACT: Among the mechanisms of insecticide resistance, knockdown resistance (kdr), causes alterations in the functioning of the voltage-gated sodium channel (Nav), which is the target site for pyrethroids (PYs) and dichloro diphenyl chloroethane (DDT). In Aedes aegypti, 13 kdr mutations associated with PYs resistance have been identified, with V₄₁₀L, V₁₀₁₆I, V₁₀₁₆G, and F₁₅₃₄C being the most reported mutations in the literature. To assess global and temporal trends in the allelic frequencies of these V₄₁₀L, V₁₀₁₆I/G and F₁₅₃₄C mutations, a PRISMA-guided systematic review was conducted to analyzed their distribution and frequency, incorporating new genotyping data from five southeastern Brazilian popu

SUBMITTER: Valencia-Marin BS 

PROVIDER: S-EPMC12657815 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature