Modelling the influence of vitamin D and probiotics on inflammation and the intestinal microbiota in older adults.

ABSTRACT: The relationship between the intestinal microbiota and human health during ageing is an area of increasing interest due to increasing health challenges experienced by ageing populations. This paper develops a mathematical model describing the age-related biological changes associated with alterations to the microbiota, vitamin D levels, immunosenescence and inflammageing to determine the likely impact of manipulating the intestinal microbiota with dietary components. Age-dependent parameters are incorporated into a previously developed model to determine the evolution of intestinal bacterial populations, vitamin D receptor:1,25 dihydroxyvitamin D levels, epithelial barrier integrity and immune response with increasing age. Results suggest an age-related decline in both innate and adaptive

SUBMITTER: Franks S 

PROVIDER: S-EPMC12657869 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature