A positive feedback loop between TNS1 and ZEB1 promotes TGFβ-induced epithelial-to-mesenchymal transition in lung cancer.

ABSTRACT: Epithelial-mesenchymal transition (EMT) plays a pivotal role in tumor metastasis initiation. Although emerging evidence suggests that Tensin-1 (TNS1) contributes to tumor metastasis, its precise function in EMT during lung cancer progression and the underlying mechanisms remain unclear. Here, we identify that TNS1 is upregulated in a TGFβ-induced EMT cell model. Functional studies demonstrate that TNS1 knockdown significantly attenuates both TGFβ- and hypoxia-induced EMT, highlighting its critical role in this process. Furthermore, TNS1 overexpression promotes EMT and enhances the metastatic potential of lung cancer cells in vitro and in vivo, while knockdown of TNS1 exhibits opposite effects. Mechanistically, TNS1 upregulation during TGFβ- mediated EMT is found to be transcriptionally reg

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12657872 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature