Mitotic dynamics of the nuclear lamina in the backstage of chromosome separation.

ABSTRACT: The regulation of mitosis is essential for genome inheritance and stability. In mammals, many cellular ultrastructures, including the nuclear envelope, undergo significant morphological changes to facilitate chromosome separation. In particular, the lamina, a key nuclear envelope subcompartment, experiences drastic structural changes throughout mitosis, from its rapid and complete dissociation during the nuclear envelope breakdown to its reassembly during mitotic exit. Interestingly, intermediate states of assembly of both A and B-type lamins, the major components of the lamina, have been reported to support mitotic progression and spindle formation. Here we review the various contributions of lamins to mitosis, beyond nuclear envelope breakdown and reassembly. In addition, we discuss how

SUBMITTER: Picotto J 

PROVIDER: S-EPMC12657873 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature