Pro-inflammatory cytokine profiles and neutralizing antibodies in JYNNEOS-vaccinated and mpox-diagnosed individuals.

ABSTRACT: Mpox is a significant health concern as an infectious disease. Therefore, understanding the immune response triggered in individuals vaccinated with JYNNEOS and those diagnosed with mpox requires further investigation. In this study, we evaluated neutralizing antibody (nAb) titers and profiles of pro-inflammatory and anti-inflammatory cytokines in JYNNEOS-vaccinated individuals with and without prior exposure to poxvirus, as well as in those who were unvaccinated and diagnosed with mpox. Samples were collected from 23 individuals at multiple time points, before vaccination (D0) and after vaccination (D7, D14, D30, D60, and D150), along with 8 samples from individuals with mpox. We observed a significant increase in nAb titers in naive-vaccinated individuals at D60, followed by a long-term

SUBMITTER: Maciel MSC 

PROVIDER: S-EPMC12657927 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature