Impact of zinc and chromium deficiency on gene expression in type 2 diabetes mellitus.

ABSTRACT: The increasing prevalence of type 2 diabetes mellitus (T2DM), largely attributable to poor dietary habits and nutritional imbalances, highlights the need for novel diagnostic and therapeutic approaches. Emerging evidence emphasizes the critical role of trace elements in the pathogenesis and management of T2DM. However, the molecular mechanisms through which zinc and chromium deficiencies contribute to disease progression remain largely unexplored. This study aimed to investigate the role of zinc and chromium in T2DM pathogenesis through a combination of bioinformatics analysis, molecular docking, trace element profiling, and gene expression validation. Relevant genes identified from the literature were analyzed using a bioinformatics pipeline to uncover hub gene networks and regulatory pat

SUBMITTER: Nayyar H 

PROVIDER: S-EPMC12657930 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature