Inflammatory response in bacteremia survivors and non-survivors: a case-control study.

ABSTRACT: Survival in bacteremia is influenced by host comorbidities, pathogen virulence, immune response, and the quality of medical care. A deeper understanding of host inflammatory responses may help identify new biomarkers and therapeutic targets to improve outcomes. In this study, we analyzed plasma samples from adult patients with bacteremia who presented to the emergency department. Patients who died within seven days (n = 44) were compared to matched survivors (n = 44) who lived at least 90 days, with matching based on age, sex, and causative bacterium. Relative concentrations of 92 inflammation-related plasma proteins were measured using the proximity extension assay (Olink Proteomics AB). Of these, 82 proteins were successfully quantified. Thirty proteins, including IL-20RA, CD40, and HGF,

SUBMITTER: Ojanen MJ 

PROVIDER: S-EPMC12657952 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature