Signs of immune dysregulation in second-trimester maternal blood RNA profiles in late-onset preeclampsia.

ABSTRACT: Preeclampsia (PE) is a hypertensive disorder that affects 5% of pregnancies. It is characterized by new-onset hypertension and proteinuria after 20 weeks of gestation. We investigated maternal second-trimester peripheral blood gene expression profiles to identify potential biomarkers for predicting late-onset PE. We found significant associations between PE and several inflammatory and immunological pathways, including the JAK-STAT signaling, leukocyte transendothelial migration, systemic lupus erythematosus (SLE), and graft versus host disease (GVHD). Twelve candidate biomarkers were identified, with high predictive power (AUC 0.74-0.87) for late-onset PE. These biomarkers were also associated with various blood cell populations, particularly intermediate monocytes. Our study highlights t

SUBMITTER: Gunaydin GY 

PROVIDER: S-EPMC12658047 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature