A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models.

ABSTRACT: Timely infiltration and effective turnover of macrophages after trauma are essential for wound regeneration. In pathological conditions, such as diabetic wounds, how disturbances in cellular collaboration leads to persistent inflammatory infiltration remains unclear. Herein, we identify that the expression of methionine adenosyltransferase 2 A (MAT2A), which is downregulated in pericytes, is negatively correlated with inflammatory macrophage infiltration in diabetic wounds. Cspg4-CreER^T2/+; Mat2a^flox/flox female mouse model and single-cell sequencing of its wound tissue reveal that TAM induced-Mat2a deficiency in pericytes induces cell senescence and further drives the inflammatory trained immunity of infiltrating macrophages through senescence-associated secretory ph

SUBMITTER: Lv D 

PROVIDER: S-EPMC12658056 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature