Predictive value of subharmonic-aided pressure estimation for diagnosing clinically significant portal hypertension.

ABSTRACT: Subharmonic-aided pressure estimation (SHAPE) is an innovative ultrasound-based method using contrast agents to assess the severity of portal hypertension (PH). This study aimed to evaluate the predictive value of the revised SHAPE method for diagnosing clinically significant PH (CSPH; hepatic venous pressure gradient [HVPG] ≥ 10 mmHg). This cross-sectional study included 62 patients with chronic liver disease who underwent HVPG, liver stiffness, and spleen stiffness (SSM) measurements. Cutoff values for high sensitivity and specificity were derived to rule in CSPH. The SHAPE gradient showed a strong correlation with HVPG (r = 0.74, p < 0.01). Patients with CSPH had a significantly higher SHAPE gradient than those without CSPH (- 1.6 dB versus - 5.1 dB; p < 0.01). The optimal cutoff value

SUBMITTER: Nakamura Y 

PROVIDER: S-EPMC12658092 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature