A practical prescription for magnetic resonance microscopy in a horizontal bore magnet.

ABSTRACT: Magnetic resonance microscopy (MRM) produces high spatial resolution proton images of biological tissues, plants, and porous media, revealing microstructural details and contrast unattainable by other means. A major challenge in MRM is the low signal-to-noise ratio at high spatial resolutions, as smaller voxels produce smaller MR signals. This necessitates the use of highly sensitive microcoils, high-performance gradient systems, and high magnetic fields. Here, we present a step-by-step prescription for fabricating a cost-effective, flexible microimaging probe system compatible with horizontal bore high-field MRI systems. We demonstrate performance at 15.2 T by acquiring high-resolution (15 μm isotropic voxels) images of ex vivo mouse spinal cord (gray matter SNR 38; 46 h scan) and hippoca

SUBMITTER: Dhakal B 

PROVIDER: S-EPMC12658110 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature