Dysbiosis of gut microbiota in children with functional constipation and damp-heat constitution: a cross-sectional multi-omics analysis.

ABSTRACT: Functional constipation (FC), a prevalent gastrointestinal disorder in early childhood associated with gut microbial dysbiosis, shows significant connections with specific constitutional types in Traditional Chinese Medicine (TCM). While TCM's nine constitutional classifications identify damp-heat constitution as a potential risk factor for FC, pediatric-specific evidence remains scarce regarding this correlation. Using the Constitutional Medicine Questionnaire, 49 children under 2 years were stratified into two groups: 18 children with damp-heat constitution who suffered from constipation (DHC) and 31 children with balanced constitution who did not suffer from constipation (BC). Clinical assessments (Bristol Stool Scale, symptom profiles), gut microbial profiling (16 S rRNA sequencing), a

SUBMITTER: Zhao H 

PROVIDER: S-EPMC12658172 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature