Unraveling the mesoscale resting-state functional connectivity of ocular dominance columns in humans using high-resolution functional MRI.

ABSTRACT: Despite their importance for visual perception, functional connectivity between ocular dominance columns in human primary visual cortex remains largely unknown. Using high-resolution functional MRI, we localize ocular dominance columns and assess their resting-state functional connectivity in 12 human adults. Consistent with anatomical studies in animals, we find stronger connectivity in middle compared to deep and superficial cortical depths and selectively stronger connectivity between columns with alike compared to unalike ocular polarity. Beyond what was known from animal models, and consistent with human perceptual biases, intra- and interhemispheric connectivity is stronger in peripheral (compared to central) and in dorsal (compared to ventral) subregions. Lastly, connectivity patter

SUBMITTER: Schmidt ME 

PROVIDER: S-EPMC12658184 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature