EZH2 expression in hepatocellular carcinoma and its relationship with circadian rhythm-related genes.

ABSTRACT: Hepatocellular carcinoma (HCC) is the most prevalent liver malignancy, with increasing incidence and high mortality, primarily associated with hepatitis virus infection and cirrhosis. Herein, we explored the association between enhancer of zeste homolog 2 (EZH2) expression and HCC progression, prognosis, and circadian rhythm-related genes. Differentially expressed mRNAs in HCC were identified from The Cancer Genome Atlas and Gene Expression Omnibus databases and intersected with circadian rhythm-related genes. Core genes were screened using protein-protein interaction networks, least absolute shrinkage and selection operator regression, and Cox regression analysis. Functional enrichment and immune infiltration analyses were conducted using gene set variation analysis, single-sample gene se

SUBMITTER: Wang X 

PROVIDER: S-EPMC12658187 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature