Glutamate, NAA, and energy metabolism in clinical high risk and first episode psychosis.

ABSTRACT: Regulation of brain glutamate is closely related to brain energy metabolism. Changes in both central glutamatergic function and peripheral energy metabolism have been implicated in psychosis risk, onset and long-term illness, but there is a lack of empirical evidence to link these processes. We investigated the relationships between glutamate and N-acetyl-aspartate (NAA, a potential marker of neuronal metabolic integrity) in the anterior cingulate cortex (ACC), measured using proton magnetic resonance spectroscopy (¹H-MRS), and peripheral markers of energy metabolism (mitochondrial complex I-V content, pyruvate and lactate) in individuals either at clinical high risk for psychosis or in the first episode of psychosis (N = 36) and healthy controls (N = 20). ACC Glx (glutamate + g

SUBMITTER: King B 

PROVIDER: S-EPMC12658253 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature